Multiscale Granuloma Simulations
[ Multiscale Granuloma Simulations Homepage | Kirschner Lab Time-Lapse Simulations Homepage | GranSim ]




Please utilize your web browser's ZOOM feature to
manually optimize the display of this webpage to
your screen resolution






Movie 1: Control of Mtb infection within a well-circumscribed granuloma

The movie shows 200 days of granuloma formation and infection dynamics after a macrophage at the center of grid becomes infected with Mtb. The grid represents a two-dimensional section of lung parenchyma with an area of 2 mm x 2 mm. Immune cells are recruited from vascular sources distributed on the parenchyma.


To play the movie, click on the graphic image above

Right click or CTRL-click on AVI icon,
select "Save Link As" or "Save Target As"
to download the archived AVI movie file version of
Movie 1.



To extract the AVI movie from the archive, download the archive
to your Mac or Windows desktop, double-click on them, and follow the
on-screen instructions.

To extract on Linux, Unix, BSD, etc... use the command in a shell
'unzip (filename.zip)' or a desktop extraction utility.






Movie 1

Movie 2
Control of Mtb infection within a
well-circumscribed granuloma

Clearance of Mtb

Movie 3

Movie 4
Uncontrolled growth of Mtb due to TNF deletion

Uncontrolled growth of Mtb due to IFN-γ deletion

Movie 5

Movie 6
Clearance of Mtb with extensive inflammation
at very slow rates of TNFR1 internalization

Clearance of Mtb at slow rates of
TNFR1 internalization

Movie 7

Movie 8
Containment of Mtb within the granuloma at
physiological rate of TNFR1 internalization

Uncontrolled growth of Mtb at rapid
rates of TNFR1 internalization



[ Multiscale Granuloma Simulations Homepage | Kirschner Lab Time-Lapse Simulations Homepage | GranSim ]