Multiscale Granuloma Simulations
[ Multiscale Granuloma Simulations Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]




Movie 1: Control of Mtb infection within a well-circumscribed granuloma

The movie shows 200 days of granuloma formation and infection dynamics after a macrophage at the center of grid becomes infected with Mtb. The grid represents a two-dimensional section of lung parenchyma with an area of 2 mm x 2 mm. Immune cells are recruited from vascular sources distributed on the parenchyma.

Search engine friendly content
To play the movie, click on the graphic image above

Right click or CTRL-click on AVI icon,
select "Save Link As" or "Save Target As"
to download the archived AVI movie file version of
Movie 1.


Flash time-lapse simulations are best played using Flash version 8 or greater

To extract the AVI movie from the archive, download the archive
to your Mac or Windows desktop, double-click on them, and follow the
on-screen instructions.

To extract on Linux, Unix, BSD, etc... use the command in a shell
'unzip (filename.zip)' or a desktop extraction utility.






Movie 1

Movie 2
Control of Mtb infection within a
well-circumscribed granuloma

Clearance of Mtb

Movie 3

Movie 4
Uncontrolled growth of Mtb due to TNF deletion

Uncontrolled growth of Mtb due to IFN-&gamma deletion

Movie 5

Movie 6
Clearance of Mtb with extensive inflammation
at very slow rates of TNFR1 internalization

Clearance of Mtb at slow rates of
TNFR1 internalization

Movie 7

Movie 8
Containment of Mtb within the granuloma at
physiological rate of TNFR1 internalization

Uncontrolled growth of Mtb at rapid
rates of TNFR1 internalization



[ Multiscale Granuloma Simulations Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]