Multiscale Granuloma Simulations

Multiscale Granuloma Simulations
[ Multiscale Granuloma Simulations Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]

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Movie 3: Uncontrolled growth of Mtb due to TNF deletion

Simulation of gene knockouts of TNF or TNFR1 (k_synthMac = k_synthTcell = 0 or TNFR1_mac = TNFR1_Tcell = 0) leads to uncontrolled growth of Mtb. In this case, granulomas that form are greater in size, irregular in structure and include very high numbers of extracellular Mtb, large numbers of infected macrophages and wide-spread caseation.

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Movie 1	Movie 2
Control of Mtb infection within a well-circumscribed granuloma	Clearance of Mtb
Movie 3	Movie 4
Uncontrolled growth of Mtb due to TNF deletion	Uncontrolled growth of Mtb due to IFN-γ deletion
Movie 5	Movie 6
Clearance of Mtb with extensive inflammation at very slow rates of TNFR1 internalization	Clearance of Mtb at slow rates of TNFR1 internalization
Movie 7	Movie 8
Containment of Mtb within the granuloma at physiological rate of TNFR1 internalization	Uncontrolled growth of Mtb at rapid rates of TNFR1 internalization

[ Multiscale Granuloma Simulations Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]