Multiscale Granuloma Simulations

Multiscale Granuloma Simulations
[ Multiscale Granuloma Simulations Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]

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Movie 7: Containment of Mtb within the granuloma
at physiological rate of TNFR1.

A moderate (physiological) rate of sTNF-induced TNFR1 internalization (half-time of ~15 min, k_int1 = 7.7 x 10^-4 s^-1) leads to containment of Mtb..

To play the movie, click on the graphic image above

Right click or CTRL-click on AVI icon,
select "Save Link As" or "Save Target As"
to download the archived AVI movie file version of
Movie 7.

To extract the AVI movie from the archive, download the archive
to your Mac or Windows desktop, double-click on them, and follow the
on-screen instructions.

To extract on Linux, Unix, BSD, etc... use the command in a shell
'unzip (filename.zip)' or a desktop extraction utility.

Movie 1	Movie 2
Control of Mtb infection within a well-circumscribed granuloma	Clearance of Mtb
Movie 3	Movie 4
Uncontrolled growth of Mtb due to TNF deletion	Uncontrolled growth of Mtb due to IFN-γ deletion
Movie 5	Movie 6
Clearance of Mtb with extensive inflammation at very slow rates of TNFR1 internalization	Clearance of Mtb at slow rates of TNFR1 internalization
Movie 7	Movie 8
Containment of Mtb within the granuloma at physiological rate of TNFR1 internalization	Uncontrolled growth of Mtb at rapid rates of TNFR1 internalization

[ Multiscale Granuloma Simulations Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]