Multiscale Granuloma Simulations
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Movie 7: Containment of Mtb within the granuloma
at physiological rate of TNFR1.

A moderate (physiological) rate of sTNF-induced TNFR1 internalization (half-time of ~15 min, kint1 = 7.7 x 10-4 s-1) leads to containment of Mtb..


To play the movie, click on the graphic image above

Right click or CTRL-click on AVI icon,
select "Save Link As" or "Save Target As"
to download the archived AVI movie file version of
Movie 7.



To extract the AVI movie from the archive, download the archive
to your Mac or Windows desktop, double-click on them, and follow the
on-screen instructions.

To extract on Linux, Unix, BSD, etc... use the command in a shell
'unzip (filename.zip)' or a desktop extraction utility.






Movie 1

Movie 2
Control of Mtb infection within a
well-circumscribed granuloma

Clearance of Mtb

Movie 3

Movie 4
Uncontrolled growth of Mtb due to TNF deletion

Uncontrolled growth of Mtb due to IFN-γ deletion

Movie 5

Movie 6
Clearance of Mtb with extensive inflammation
at very slow rates of TNFR1 internalization

Clearance of Mtb at slow rates of
TNFR1 internalization

Movie 7

Movie 8
Containment of Mtb within the granuloma at
physiological rate of TNFR1 internalization

Uncontrolled growth of Mtb at rapid
rates of TNFR1 internalization



[ Multiscale Granuloma Simulations Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]