Dr. Kirschner has been a professor in the dept of Microbiology and Immunology at the University of Michigan for 25 years. She received her Bachelors, Masters and PhD in applied mathematics from Tulane University. She did graduate work also at Los Alamos National Labs and a postdoctoral fellowship at Vanderbilt University joint with the departments of Mathematics and Infectious Diseases. For the past 25 years, her research focus has been on building multi-scale models to describe the host immune response to M. tuberculosis at multiple spatial and time scales and in multiple physiological sites including lung, lymph nodes and blood. To date she has worked and collaborated with experimentalists generating data on TB with mouse, non-human primate and human studies. Dr. Kirschner currently serves (and has for the past 20 years) as Editor-in-Chief of the Journal of Theoretical Biology. She serves as the founding co-director of The Center for Systems Biology at the University of Michigan, an interdisciplinary center at the University of Michigan aimed to facilitate research and training between wet-lab and theoretical scientists.
Co-Chief Editor
Journal of Theoretical Biology
Past President
Society for Mathematical Biology
Congratulations to Dr. Kirschner
who was named an inaugural
Fellow of the SMB (2017)
and a 2021 SIAM Fellow
Co-Director
Center for Systems Biology

My Commitment to Diversity, Equity and Inclusion: Within my laboratory, we strive to create a lab that values and includes people with diverse backgrounds, beliefs, and experiences. Our lab seeks to recruit, support, and retain members from diverse backgrounds and groups that have historically been underrepresented in the sciences. As a team, we are committed to creating a learning and working environment where individuals feel supported and invested in the lab mission. This is a dynamic process, and we are continuously striving to improve our efforts toward these goals.

My Mission: To educate others and promote women, math and family values in the scientific community.













My Favorite Quotes:

  • My Life is ALL math: I spend my time trying to add to my income, divide my time, subtract some weight, and avoid multiplying.
  • All good things come from Brooklyn, and never return there.





  • Feature Projects:
    A multi-scale model to predict outcomes of immuno-modulation and drug therapy during TB
    funded by a Multi-scale Modeling Consortium grant sponsored by the National Institutes of Health

    A Multi-scale and multi-system approach to understand granuloma formation in TB


    University of Michigan

    UofM Medical School

    UofM Rackham Graduate School

    UofM Microbiology & Immunology

    UofM Libraries

    UofM Computing Services

    UofM Maps

    Denise E. Kirschner, PhD
    Microbiology and Immunology
    University of Michigan
    Medical School
         6730 Medical Science Building II
    Ann Arbor, MI 48109-5620
    Phone: (734) 647-7722   Fax: (734) 647-7723
    E-mail: kirschne@umich.edu