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* Video Presentations: Dr. Denise E. Kirschner - Online Colloquium: Denise Kirschner - Building, Analyzing and Calibrating Multi-Scale Models in 2D and 3D: Tuberculosis as a Case Study - Apr 17th, 2019 Dr. Denise E. Kirschner - A Systems Biology Approach to Uncovering Mechanisms Governing Host-Mycobacterial Interactions during TB Infection - Apr 10th, 2013 Dr. Simeone Marino - A Systems Biology Approach to Understanding the Immune Response in Tuberculosis - Jan 30th, 2013
* Our lab in the news: Using Simulations to Find the Best Treatment Plan - Many promising antibiotics have been discovered that would potentially outperform the current standard treatment for tuberculosis (TB), which kills 1.5 million people every year. However, determining the best combination of medicines for TB treatment is challenging, expensive and time-consuming. For the past three decades, University of Michigan Professor of Microbiology and Immunology Denise Kirschner has been working on an array of research projects related to TB - including how best to configure appropriate treatments for TB patients using computational modeling. - April 4, 2024 - (Also found at this: Link) Multiscale Modelers Convene at NIH - The spark in 2003 that launched the Interagency Modeling and Analysis Group (IMAG) has flared into a potent scientific catalyst and not only among the multiple federal agencies that fund computational modeling of biomedical, biological and behavioral systems, including NIH, the National Science Foundation, NASA and the Department of Energy. - August, 2023 Calculating Better Tuberculosis Treatments - Denise Kirschner developed an equation-based lung model of a fatal but forgotten infectious disease, revealing an unexpected role for math in drug discovery. - March, 2023 Dr. Denise Kirschner on the first Whole Lung Simulator Helping to Predict New Treatments and Vaccines for TB - Dr. Kirschner is a professor in the dept of Microbiology and Immunology at the University of Michigan. She is Editor-in-Chief of the Journal of Theoretical Biology and the founding co-director of The Center for Systems Biology at the University of Michigan, an interdisciplinary center at the University of Michigan aimed to facilitate research and training between wet-lab and theoretical scientists. - December 5, 2022 Michigan Researchers Predict New Treatments and Vaccines for TB - University of Michigan research team is first to perform virtual clinical trials using a multi-scale lung model. - November 7, 2022 How a virtual monkey lung could advance treatment for a centuries-old global threat - A team of researchers say they've made a breakthrough that could speed up the search for more effective treatments and vaccines for the world's No. 1 infectious killer. Using mathematics, the team of University of Michigan researchers and their partners around the globe have developed a whole lung simulation capable of reproducing activity in the lungs, lymph nodes, and blood vessels during a pulmonary Tuberculosis (TB) infection. - November 5, 2022 First-of-its-kind Whole Lung Simulator is Helping Michigan Researchers Predict New Treatments and Vaccines for TB - A Reemerging Global Health Threat - University of Michigan research team is first to perform virtual clinical trials using a multi-scale lung model, with early results expected next year - October 24, 2022 Multiscale Models Shed Light on Tuberculosis - As demonstrated by the ongoing COVID-19 pandemic, a thorough understanding of infectious diseases requires data and models on multiple interconnected levels. Epidemiology addresses population-level issues, transmission models describe individuals within their environments, and a variety of biomedical approaches help researchers comprehend the way in which pathogens infiltrate the body - and the body's ability to fight back. - October 3, 2022 Computational Models Move Researchers Closer to Tuberculosis Vaccine - Expanse Supercomputer Spotlights Role of Unstable Cells in Response to Infection - January 12, 2022 XSEDE Supercomputer Simulations Help Combat Tuberculosis (TB) Granulomas - University of Michigan Team Uses Comet and Stampede2 to Create TB-Formation Models - May 29, 2019 SMB 2018 Podcast with Denise Kirschner, Timothy Wessler and Louis Josllyn - Podcast for the 2018 Annual Meeting of the Society for Mathematical Biology (SMB) and the Japanese Society for Mathematical Biology (JSMB) at the University of Sydney, Sydney, New South Wales, Australia.- 2018 From 'Biomedical Picture of the Day' - http://bpod.mrc.ac.uk   Associated article: Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach, PLOS: Computational Biology How computer scientists are setting the stage to end tuberculosis - March 31st, 2017 - American Society for Microbiology Scientists develop computer models to unravel the complexities of TB infection Contact - Models aim to identify targets for new drugs, biomarkers to predict transition to active infection - 2016 University researchers find more effective treatment method for tuberculosis - University researchers have found a way to decrease resistance to tuberculosis antibiotics - December 2nd, 2015 - The Michigan Daily Tuberculosis: Daily antibiotics recommended to prevent resistant strains - Computer modeling reveals the immune system's battleground - November 23rd, 2015 - University of Michigan : Michigan News JoAnne Flynn and Denise Kirschner at the AAI StoryBooth 2014 - Dr. Flynn is a professor in the Department of Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine, and Dr. Kirschner is a professor in the Department of Microbiology and Immunology at the University of Michigan Medical School. - 2014 Youtube AAI Channel Open Science Grid - Using the OSG to investigate the human immune response to infection with M. tuberculosis - 2013 Women Representation in Mathematical Biology - Denise Kirschner talks with Santiago Schnell about her work in mathematical biology, and the challenges facing women in applied mathematics - January 2013, Vol 26, Number 1, pages 7 and 8, Society for Mathematical Biology Newsletter Peering into the black box of Tuberculosis - Computer modeling reveals the immune system's battleground - September 21st, 2012 - University of Michigan Engineering Where Tuberculosis Meets Computation: 10 Points of Intersection - Summer 2012 - Biomedical Computation Review The above news item is supportive of the research publications and information you will find at ... 1. Our 'A Multi-scale model to predict outcomes of immuno-modulation and drug therapy during TB' webpages 2. Our 'A Multi-scale and multi-system approach to understand granuloma formation in TB' webpages 3. Our publication webpages TB bug inhibits any which way - March 21, 2005 - Rockefeller University Press Malignant Maths - Mathematical models aid the understanding of cancer - Jan 22nd, 2004 - The Economist Genetic mutation influences spread of AIDS, says U-M scientist - African population lacks mutation; may be more susceptible to HIV infection - August 24th, 2001 - University of Michigan Health System News New HIV Model Shows Virus Doesn't Kill White Blood Cells, It Just "Homes" Them to Death - HIV uses homing to kill white blood cells - September, 5th, 2000 - University of Michigan Health System News Using Mathematics to Understand a Speciies of Bacteria That Can Add Up to Big Trouble: - Helicobacter pylori is Sometimes Hard to Stomach - Winter 2000 - Medicine at Michigan
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