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An online supplement for Neutrophil dynamics affect Mycobacterium tuberculosis granuloma outcomes and dissemination

[ Video Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]

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Video 7C: Granuloma undergoing dissemination (days 19 to 21 PI)

To play the video, click on the graphic image above Formation of disseminated granuloma begins. One hour and 40 minutes into day 19 PI, a resting macrophage phagocytoses the extracellular Mtb left behind when an infected neutrophil died. When the macrophage phagocytoses the extracellular Mtb, it changes color from green (for resting macrophage) to orange (for infected macrophage). Shown are the 2D xy-locations of the simulated agents over time, from days 19 to 21 PI. Macrophages (green -- resting, orange -- infected, red -- chronically infected, blue -- activated), T cells (cantaloupe -- Tgam, maroon -- Tcyt, cyan -- Treg), extracellular Mtb (brown cross). Cells infected with Mtb are outlined in black. Caseum not shown.

Time-lapse videos corresponding to Figure 3 snapshots in main paper. These are 6 different simulations of granulomas including neutrophils and showing different outcomes. Click on the individual video links below for additional details. GranSim produces simulated granulomas that reflect granulomas in experimentally-infected macaques.
Video 3A	Video 3B
Video 3C	Video 3D
Video 3E	Video 3F
Dissemination time-lapse videos corresponding to Figure 7A snapshot in main paper. GranSim produces simulated granulomas that reflect granulomas undergoing dissemination in experimentally-infected macaques. These three videos highlight different timeframes post-infection during the evolution of a sample neutrophil-facilitated dissemination of a granuloma. Click on the video links below for additional details.
Video 7A	Video 7B
Video 7C

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[ Video Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]