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An online supplement for Neutrophil dynamics affect Mycobacterium tuberculosis granuloma outcomes and dissemination

[ Video Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]

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Video 7A: Granuloma undergoing dissemination (days 0 to 200 PI)

To play the video, click on the graphic image above Evolution of a disseminating granuloma over the first 200 days post-infection. An infected neutrophil dies and leaves extracellular Mtb on the grid around day 7-8 PI, and a resting macrophage eventually phagocytoses the extracellular Mtb on day 19 PI. This prompts the formation/growth of a disseminated granuloma, before T cells arrive and the adaptive immune response begins. Shown are the 2D xy-locations of the simulated agents over time, from days 0 to 200 PI. Macrophages (green -- resting, orange -- infected, red -- chronically infected, blue -- activated), T cells (cantaloupe -- Tgam, maroon -- Tcyt, cyan -- Treg), extracellular Mtb (brown cross), caseum (grayscale).

Time-lapse videos corresponding to Figure 3 snapshots in main paper. These are 6 different simulations of granulomas including neutrophils and showing different outcomes. Click on the individual video links below for additional details. GranSim produces simulated granulomas that reflect granulomas in experimentally-infected macaques.
Video 3A	Video 3B
Video 3C	Video 3D
Video 3E	Video 3F
Dissemination time-lapse videos corresponding to Figure 7A snapshot in main paper. GranSim produces simulated granulomas that reflect granulomas undergoing dissemination in experimentally-infected macaques. These three videos highlight different timeframes post-infection during the evolution of a sample neutrophil-facilitated dissemination of a granuloma. Click on the video links below for additional details.
Video 7A	Video 7B
Video 7C

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[ Video Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]