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An online supplement for Neutrophil dynamics affect Mycobacterium tuberculosis granuloma outcomes and dissemination

[ Video Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]

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Video 3D:

To play the video, click on the graphic image above Legend: Time-lapse of a simulated granuloma during the first 200 days post-infection (sample drawn from the full parameter set, see Table 1 and Appendix Table 1). This video corresponds to the granuloma shown in Figure 3, panel D. Here, we use a color scheme that distinguishes among the different simulated cell types: Macrophages (green-- resting, orange-- infected, red-- chronically infected, blue-- activated), Neutrophils (purple), T cells (Tgam-- pink, Tcyt-- maroon, Treg-- cyan), extracellular Mtb (brown), and caseum (beige) are shown.

Time-lapse videos corresponding to Figure 3 snapshots in main paper. These are 6 different simulations of granulomas including neutrophils and showing different outcomes. Click on the individual video links below for additional details. GranSim produces simulated granulomas that reflect granulomas in experimentally-infected macaques.
Video 3A	Video 3B
Video 3C	Video 3D
Video 3E	Video 3F
Dissemination time-lapse videos corresponding to Figure 7A snapshot in main paper. GranSim produces simulated granulomas that reflect granulomas undergoing dissemination in experimentally-infected macaques. These three videos highlight different timeframes post-infection during the evolution of a sample neutrophil-facilitated dissemination of a granuloma. Click on the video links below for additional details.
Video 7A	Video 7B
Video 7C

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[ Video Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]