MultiGran: a computational model that tracks
multiple granulomas within the lung
[ MultiGran Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]


Movie 1: ViewCenter

A single in silico simulation across 250 days following infection (anterior view) plotted over a data grid taken from PET/CT images of a single NHP. Granulomas are located in 3D space wherein each circle of a single color represents a granuloma with a single Mtb barcode ID. The circle shown as a pie chart represents a granuloma cluster with two unique Mtb barcode IDs. Inoculation was in the lower right lung (bottom left in image of simulation). Granulomas found in upper lung region result from non-local dissemination within the simulation.

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Movie 1
Movie 2
A single in silico simulation across 250 days following infection (anterior view) plotted over a data grid taken from PET/CT images of a single NHP. Granulomas are located in 3D space wherein each circle of a single color represents a granuloma with a single Mtb barcode ID. The circle shown as a pie chart represents a granuloma cluster with two unique Mtb barcode IDs. Inoculation was in the lower right lung (bottom left in image of simulation). Granulomas found in upper lung region result from non-local dissemination within the simulation.


 A single in silico simulation across 250 days following infection (same as Movie 1, just shown in posterior-lateral view) plotted over a data grid taken from PET/CT images of a single NHP. Granulomas are located in 3D space wherein each circle of a single color represents a granuloma with a single Mtb barcode ID. The circle shown as a pie chart represents a granuloma cluster with two unique Mtb barcode IDs. Inoculation was in the lower right lung (bottom left in image of simulation). Granulomas found in upper lung region result from non-local dissemination within the simulation.



Movie 3
A single in silico simulation across 250 days following infection (same as Movie 1/2, just shown in opposite posterior-lateral view) plotted over a data grid taken from PET/CT images of a single NHP. Granulomas are located in 3D space wherein each circle of a single color represents a granuloma with a single Mtb barcode ID. The circle shown as a pie chart represents a granuloma cluster with two unique Mtb barcode IDs. Inoculation was in the lower right lung (bottom left in image of simulation). Granulomas found in upper lung region result from non-local dissemination within the simulation.




[ MultiGran Homepage | Kirschner Lab Time-Lapse Simulations Homepage ]