M. tuberculosis Granuloma Simulations

an on-line supplement for

Identifying control mechanism of granuloma formation during M. tuberculosis infection using an agent based model

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Jose L. Segovia-Juarez, Suman Ganguli, and Denise Kirschner, Identifying control mechanism of granuloma formation during M. tuberculosis infection using an agent based model, Journal of Theoretical Biology. 231, Issue 3, pp 357-376, 2004, DOI: 10.1016/j.jtbi.2004.06.031, PMID: 15501468, PMCID: (exempt)




1. clearance.avi.zip (7MB) shows what happens to the granuloma when the immune system is able to destroy the bacteria.
2. containment.avi.zip (67MB) shows granuloma formation when infection is contained.
3. dissemination.avi.zip (67MB) shows what happens to the granuloma when the infection is not contained.

The colors represent resting macrophages (green), activated macrophages (blue), infected macrophages (orange), chronically infected macrophages (red), T cells (pink), necrotic tissue (brown) and extracellular bacteria (yellow). Movies are one frame/day,  up to 500 days in the containment and dissemination simulations.



Created by Jose L. Segovia-Juarez, Suman Ganguli and Denise Kirschner, 2004.