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M. tuberculosis Granuloma Simulations

an on-line supplement for

Identifying control mechanism of granuloma formation during M. tuberculosis infection using an agent based model

[ Denise Kirschner's Homepage | Kirschner Lab Homepage ]




Jose L. Segovia-Juarez, Suman Ganguli, and Denise Kirschner, Identifying control mechanism of granuloma formation during M. tuberculosis infection using an agent based model, Journal of Theoretical Biology. 231, Issue 3, pp 357-376, 2004, DOI: 10.1016/j.jtbi.2004.06.031, PMID: 15501468, PMCID: (exempt)






1. clearance.avi.zip (7MB) shows what happens to the granuloma
when the immune system is able to destroy the bacteria.

The colors represent resting macrophages (green), activated macrophages (blue), infected macrophages (orange), chronically infected macrophages (red), T cells (pink), necrotic tissue (brown) and extracellular bacteria (yellow). Movies are one frame/day,  up to 500 days in the containment and dissemination simulations.





2. containment.avi.zip (67MB) shows granuloma
formation when infection is contained.

The colors represent resting macrophages (green), activated macrophages (blue), infected macrophages (orange), chronically infected macrophages (red), T cells (pink), necrotic tissue (brown) and extracellular bacteria (yellow). Movies are one frame/day,  up to 500 days in the containment and dissemination simulations.





3. dissemination.avi.zip (67MB) shows what happens to the granuloma
when the infection is not contained.

The colors represent resting macrophages (green), activated macrophages (blue), infected macrophages (orange), chronically infected macrophages (red), T cells (pink), necrotic tissue (brown) and extracellular bacteria (yellow). Movies are one frame/day,  up to 500 days in the containment and dissemination simulations.


Created by Jose L. Segovia-Juarez, Suman Ganguli and Denise Kirschner, 2004.