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M. tuberculosis Granuloma Simulations
|
an on-line supplement for Identifying control mechanism of granuloma formation during M. tuberculosis infection using an agent based model |
[ Denise Kirschner's Homepage | Kirschner Lab Homepage ]
Jose L. Segovia-Juarez, Suman Ganguli, and Denise Kirschner,
Identifying control mechanism of granuloma
formation during M. tuberculosis infection using an agent based model,
Journal of Theoretical Biology. 231, Issue 3, pp 357-376, 2004,
DOI: 10.1016/j.jtbi.2004.06.031,
PMID: 15501468,
PMCID: (exempt)
|
1. clearance.avi.zip (7MB) shows what happens to the granuloma
when the immune system is able to destroy the bacteria.
| The colors represent resting macrophages (green), activated macrophages (blue), infected macrophages (orange), chronically infected macrophages (red), T cells (pink), necrotic tissue (brown) and extracellular bacteria (yellow). Movies are one frame/day, up to 500 days in the containment and dissemination simulations. |
2. containment.avi.zip (67MB) shows granuloma
formation when infection is contained.
| The colors represent resting macrophages (green), activated macrophages (blue), infected macrophages (orange), chronically infected macrophages (red), T cells (pink), necrotic tissue (brown) and extracellular bacteria (yellow). Movies are one frame/day, up to 500 days in the containment and dissemination simulations. |
3. dissemination.avi.zip (67MB) shows what happens to the granuloma
when the infection is not contained.
| The colors represent resting macrophages (green), activated macrophages (blue), infected macrophages (orange), chronically infected macrophages (red), T cells (pink), necrotic tissue (brown) and extracellular bacteria (yellow). Movies are one frame/day, up to 500 days in the containment and dissemination simulations. |
Created by Jose L. Segovia-Juarez, Suman Ganguli and Denise Kirschner, 2004.