Multiscale Anti-TNF Drugs Simulations
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Movie 6: Infection dynamics after granuloma treatment with infliximab at a high vascular permeability coefficient (kc = 1.1×10-7 cm/s)

The movie shows granuloma formation and control of infection for 100 days. Then, the granuloma is exposed to infliximab with varying concentration penetrating the grid representing lung parenchyma via vascular sources. The vascular permeability coefficient of kc = 1.1×10-8 cm/s leads to approximately 10% penetration of infliximab from blood into tissue. Change of the color of the environment represents change of available drug concentration in tissue.

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Movie 1
Movie 2
Control of Mtb infection within a
well-circumscribed granuloma in
the absence of TNF inhibitor

 Infection dynamics after granuloma treatment
with etanercept at a small vascular
permeability coefficient (kc = 1.1×10-8 cm/s)

Movie 3
Movie 4
Infection dynamics after granuloma treatment
with etanercept at a high vascular
permeability coefficient (kc = 1.1×10-7 cm/s)

 Infection dynamics after granuloma treatment
with infliximab at a small vascular
permeability coefficient (kc = 1.1×10-8 cm/s)

Movie 5
Movie 6
Infection dynamics after granuloma treatment
with infliximab at a high vascular
permeability coefficient (kc = 1.1×10-7 cm/s)

 The effect of pharmacokinetic fluctuations in
the blood concentration of infliximab
on infection dynamics for a small vascular
permeability coefficient (kc = 1.1×10-8 cm/s)

Movie 7
The effect of pharmacokinetic fluctuations in the
blood concentration of infliximab on infection
dynamics for a high vascular permeability
coefficient (kc = 1.1×10-7 cm/s)


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