Multiscale Anti-TNF Drugs Simulations
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Movie 1: Control of Mtb infection within a well-circumscribed granuloma in the absence of TNF inhibitor

The movie shows 300 days of granuloma formation and infection dynamics after a macrophage at the center of grid becomes infected with Mtb. The grid represents a two-dimensional section of lung parenchyma with an area of 2 mm x 2 mm. Immune cells are recruited from vascular sources distributed on the parenchyma.

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Movie 1
Movie 2
Control of Mtb infection within a
well-circumscribed granuloma in
the absence of TNF inhibitor

 Infection dynamics after granuloma treatment
with etanercept at a small vascular
permeability coefficient (kc = 1.1×10-8 cm/s)

Movie 3
Movie 4
Infection dynamics after granuloma treatment
with etanercept at a high vascular
permeability coefficient (kc = 1.1×10-7 cm/s)

 Infection dynamics after granuloma treatment
with infliximab at a small vascular
permeability coefficient (kc = 1.1×10-8 cm/s)

Movie 5
Movie 6
Infection dynamics after granuloma treatment
with infliximab at a high vascular
permeability coefficient (kc = 1.1×10-7 cm/s)

 The effect of pharmacokinetic fluctuations in
the blood concentration of infliximab
on infection dynamics for a small vascular
permeability coefficient (kc = 1.1×10-8 cm/s)

Movie 7
The effect of pharmacokinetic fluctuations in the
blood concentration of infliximab on infection
dynamics for a high vascular permeability
coefficient (kc = 1.1×10-7 cm/s)


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