Granuloma Simulations

an on-line supplement for

A Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection
[ Time-Lapse Simulations Homepage | Kirschner Lab Homepage ]





J. Christian J. Ray, JoAnne L. Flynn, and Denise E. Kirschner, Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection. Journal of Immunology, 2009, 182: pp 3706-3717, DOI: 10.4049/jimmunol.0802297, PMID: 19265149, PMCID: 3182770.

Errata - Table 1 | Supplemental Information - Supplement Set 1




Supplement 1: Agent-Based Model Rules 143k

Supplement 2: Detailed Methods 83k

Supplement 3: Supplementary Tables and Figures 37M

Supplement 4: Answers to questions about the article 60k




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Time-Lapse Simulation of controlled infection

Time-lapse simulation of a granuloma forming after infection with Mycobacterium tuberculosis. The field simulates a 2 mm by 2 mm slice of lung parenchyma where an infected macrophage cell initates the infection. Recruited immune cells arrive via vascular sources distributed on the parenchyma. The movie shows 200 days of infection dynamics. This simulation represents a controlled infection where a stable granuloma forms.

Right click or CTRL-click on MPEG icon, select "Save Link As" or "Save Target As" to download the archived MPEG movie file version of time-lapse simulations of controlled infection

To extract the MPEG movie from the archive, download the archive to your Mac or Windows desktop, double-click on them, and follow the on-screen instructions.

To extract on Linux, Unix, BSD, etc... use the command in a shell 'unzip (filename.zip)' or a desktop extraction utility

Flash time-lapse simulations are best played using Flash version 8 or greater



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To play the movie, click on the graphic image above


Time-Lapse Simulations of TNF Deletion

Time-lapse simulation of a granuloma forming after infection with Mycobacterium tuberculosis in the absence of tumor necrosis factor-α (TNF). This simulation has identical conditions to the control simulation (above), except that TNF is not produced by host immune cells.

Right click or CTRL-click on MPEG icon, select "Save Link As" or "Save Target As" to download the archived MPEG movie file version of time-lapse simulations of TNF Deletion

To extract the MPEG movie from the archive, download the archive to your Mac or Windows desktop, double-click on them, and follow the on-screen instructions.

To extract on Linux, Unix, BSD, etc... use the command in a shell 'unzip (filename.zip)' or a desktop extraction utility

Flash time-lapse simulations are best played using Flash version 8 or greater


[ Time-Lapse Simulations Homepage | Kirschner Lab Homepage ]