Fibroblast and Epithelial Cell Co-culture Simulations

an on-line supplement for

Computational Modeling predicts simultaneous targeting of fibroblasts and epithelial cells is necessary for successful treatment of pulmonary fibrosis

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Supplementary 1: Appendix for Paper




Movie #1 of 4


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Movie: One
Healthy tissue outcome


This simulation depicts complete epithelial cell survival for 7 days with no fibroblast proliferation of differentiation.

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Movie #2 of 4


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Movie: Two
Rapid epithelial cell death with fibroblast proliferation and differentiation


This simulation depicts rapid epithelial cell death with almost no epithelial cells surviving on day seven. Modest fibroblast proliferation occurs up to 24 hours at which time all fibroblasts have differentiated into myofibroblasts.

Right click or CTRL-click on MP4 icon, select "Save Link As" or "Save Target As" to download the archived MP4 movie file version of time-lapse simulations of controlled infection

To extract the MP4 movie from the archive, download the archive to your Mac or Windows desktop, double-click on the archive file, and follow the on-screen instructions.

To extract on Linux, Unix, BSD, etc... use the command in a shell 'unzip (filename.zip)' or a desktop extraction utility.

Flash time-lapse simulations are best played using Flash version 8 or greater


Movie #3 of 4


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Movie: Three
Gradual epithelial cell death with fibroblast proliferation


This simulation depicts gradual epithelial cell death with about 50 percent of the epithelial cells surviving on day 7. Fibroblast proliferation occurs throughout the entire duration of the simulation.

Right click or CTRL-click on MP4 icon, select "Save Link As" or "Save Target As" to download the archived MP4 movie file version of time-lapse simulations of controlled infection

To extract the MP4 movie from the archive, download the archive to your Mac or Windows desktop, double-click on the archive file, and follow the on-screen instructions.

To extract on Linux, Unix, BSD, etc... use the command in a shell 'unzip (filename.zip)' or a desktop extraction utility.

Flash time-lapse simulations are best played using Flash version 8 or greater


Movie #4 of 4


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Movie: Four
Excessive fibroblast proliferation and differentiation


This simulation depicts rapid epithelial cell death coupled with excessive fibroblast proliferation and differentiation. On day 7 of the simulation fibroblasts have reached near confluence and differentiated.

Right click or CTRL-click on MP4 icon, select "Save Link As" or "Save Target As" to download the archived MP4 movie file version of time-lapse simulations of controlled infection

To extract the MP4 movie from the archive, download the archive to your Mac or Windows desktop, double-click on the archive file, and follow the on-screen instructions.

To extract on Linux, Unix, BSD, etc... use the command in a shell 'unzip (filename.zip)' or a desktop extraction utility.

Flash time-lapse simulations are best played using Flash version 8 or greater



[ Time-Lapse Simulations Homepage | Kirschner Lab Homepage ]